Ratish Gambhira
New Orleans,LA
Summary
Persistent leader eager to lead and grow organizations. Skilled in strategic planning, problem-solving, and communication with good understanding of business principles, project management and team leadership. Collaborative with relentless work ethic.
Overview
24
24
years of professional experience
1
1
Certification
Work History
Founder/Owner
MoleQular Labs, LLC
03.2023 - Current
- Lab Director for 5 high complexity labs performing molecular testing, toxicology and Hematology.
- Assisting labs to increase their efficiency for molecular based assays by choosing cost-effective testing methods and platforms
- Establishing successful quality documentation for passing regulatory inspections with zero deficiencies.
- Consulting on successful implementation of molecular and genetic testing for various reference labs.
- Developed key operational initiatives to drive and maintain substantial business growth.
- Introduced advanced technology solutions into daily operations which led to increased productivity levels throughout company.
CLIA Lab Director and Startup Consultant
Lighthouse Lab Services
03.2020 - 12.2022
- Worked as startup consultant in setting up molecular clinical labs doing genomics and infectious disease testing including SARS-CoV-2 testing
- Demonstrated ability in writing validation plans, SOPs and summaries for various infectious diseases and genomic panel validations
- Acquired in-depth working knowledge on CLIA/COLA/CAP regulatory guidelines..
- Implemented process improvements to eliminate errors, reduce processing time, and streamline procedures.
- Provided ongoing support to clients post-implementation, ensuring long-term success of implemented solutions.
- Created and managed project plans, timelines and budgets.
- Managed client relationships through regular check-ins and updates on project progress.
Part-time CLIA Lab Director
GenoVive
12.2019 - 02.2020
- Released genetic testing reports for weight management and exercise recommendations
- Evaluated current processes regularly, identifying areas for improvement and implementing necessary changes proactively.
- Used critical thinking to break down problems, evaluate solutions and make decisions.
- Identified issues, analyzed information and provided solutions to problems.
Lab Director/Chief Scientific Officer
Dynamic Diagnostics
01.2019 - 01.2020
- Designed and implemented Quality controls systems to fulfill CLIA/COLA/CAP accreditation requirements for highly complexity testing
- Validated and implemented Pharmacogenetics (Pgx) testing using NGS technique on Miseq platform
- Validated inherited cancer panel using ArcherDx library prep on Miseq platform
- Validated and implemented Verigene RP Flex respiratory pathogen testing along with preparing IQCP and signed off on patient test reports.
General Supervisor/Manager Molecular Platforms
Stone Clinical laboratories
09.2017 - 10.2018
- Established and Validated Pharmacogenetics testing services for Stone Clinical Laboratories
- Certified in using the Agena biosystems MassARRAY platform (Mass spectroscopic method) for genotyping applications
- Proficient in performing Quality assessments, writing Validation Protocols, Standard Operating protocol (SOPs), Calibrating and maintaining instruments in accordance with Commission on Office Laboratory Accreditation (COLA)/ College of American Pathologists (CAP) guidelines
- Trained in performing HPV/CT/NG/HSV and lab developed testing on Cobas 4800 system
- Performed respiratory and GI panel assays on Biofire platforms for syndromic testing
- Trained Medical Technologists in performing pharmacogenetics/infectious disease testing
- Played key role in leadership, lab operations, product development, sales, and marketing committees.
Pharmacogenomics Lab Manager
Prima health
03.2016 - 07.2017
- Managing the workflow focusing on analytical performance of the Pharmacogenomics lab working on genotyping of Drug Metabolizing Enzymes (DMEs) related to pain management
- Acquired sound knowledge in operating/trouble shooting the Quantstudio 12K and ViiA 7 instruments for open array and real time PCR applications
- Supervising Proficiency testing (PT), Alternate testing in the lab and compiling all the related documents for reporting
- Personnel management such as managing the Med Tech work hours, competency training and troubleshooting the technical issues.
Instructor
Tulane University
01.2014 - 02.2016
- Worked on discovering non-invasive biomarkers for advanced prostate cancer patients
- Standardized protocols for isolating cell free DNA and exosomal RNA from patient plasma and urine samples
- Performed next generation sequencing (NGS) for cell-free DNA samples and analyzed using the bioinformatics pipelines
- Developed quantitative PCR/droplet digital PCR (ddPCR) techniques for validating selected targets from NGS derived data.
Research Fellow
Tulane University
02.2008 - 01.2014
- Identified and characterized envelopes of simian immunodeficiency virus (SIV) from vesicular stomatitis virus (VSV) vaccinated and SIVE660 challenged macaques using single genome amplification (SGA) technique.
- Analyzed and interpreted results using various phylogenetic techniques for characterizing envelope sequences of founder/transmitted viruses.
- Performed Fluorescence-activated cell sorting (FACS) for examining dynamics of CD4 and CD8T cells in peripheral blood and gut -derived lymphocytes of SIV infected macaques.
- Published several articles in scientific meetings and presented at different scientific meetings.
Postdoctoral Fellow
Johns Hopkins University
11.2002 - 02.2008
- Conducted research on developing L2 based prophylactic vaccines against Human papillomavirus (HPV) infection and understanding role of L2 protein in HPV infection
- Developed broadly protective protein and peptide- based vaccines against cervical cancer
- Discovered novel Monoclonal antibody (RG-1) that protected against HPV infection both in vitro and in vivo (mouse model)
- Performed extensive work on understanding mechanism of papillomavirus entry into susceptible cells using micro-arrays.
- Presented research findings at national and international conferences,
Research Trainee
MD Anderson Cancer Center
06.2000 - 11.2002
- Studied 'the safety and potential of cholera toxin mutant as novel mucosal adjuvant' in combination with peptides derived from both Human immunodeficiency virus (HIV) and HPV for eliciting T and B cell responses in mouse models
- Processed blood samples from HPV infected patients and analyzed their immune response to HPV E6 and E7 derived peptides using Enzyme-linked-immunospot assays (ELISPOT)s, FACS and T cell proliferation assays.
- Assisted with preparing project-related reports, presentations and manuscripts.
- Collaborated with researchers and scientists to design and execute experiments.
- Participated in lab meetings and project presentations.
Education
PhD - Biomedical Sciences
Tulane University
New Orleans01.2012
Master’s in veterinary sciences (M.V.Sc.) with Thesis - Animal Biotechnology
Indian Veterinary Research Institute
Izzatnagar, India01.1997
Bachelor’s veterinary Sciences (equal to DVM) - Animal Sciences
College of Veterinary Sciences
Tirupati, India01.1994
Skills
- Budget Planning
- Process Improvement
- Quality Control Planning
- Operations Management
- Client Engagement
- Team Leadership
- Staff Management
- Regulatory Compliance (CAP/CLIA/COLA)
- Consulting
Certification
- Clinical Consultant, American Board of Bioanalysis, 03/2020, Present
- High-Complexity Clinical Lab Director, American Board of Bioanalysis, 06/2019, Present
- Technical Supervisor Molecular Diagnostics, American Board of Bioanalysis, 06/2017, Present
- Technologist in Molecular Biology, American Society for Clinical Pathology, 07/2016, Present
- QA Specialist Course Program, COLA Inc., 08/2017, Present
- CLS Specialist, LSBME303318, 07/2016, Present
- Diplomate in Virology, American College of Veterinary Microbiologists, 12/2010, Present
Eligibility
US Citizen, Eligibility to work with any employer.
Patents
- Papillomavirus L2 N-terminal peptides for the induction of broadly cross-neutralizing antibodies, 8,404,244
- Multi-component L2 vaccine for prevention of human papilloma virus infection, 9,138,470
- Papillomavirus L2 N-terminal peptides for the induction of broadly cross-neutralizing antibodies, 9,388,221
Publications
- Antigenic requirement for Gag in a vaccine that protects against high-dose mucosal challenge with simian immunodeficiency virus, Schell JB, Bahl K, Diller K, Folta-Stogniew E, Rose N, Buonocore L, Marx PA, Gambhira R, and Rose JK, Virology, 02/2015
- SGA analysis of viral envelope sequences in VSV-SIV vaccinated and SIVsmE660 challenged rhesus macaques, Gambhira R, Keele BF, Schell JB, Hunter MJ, Dufour JP, Montefiori DC, Tang HK, Rose JK, Rose N and Marx PA, PLoS One, 10/2014
- Role of L2 cysteines in papillomavirus infection and neutralization, Gambhira R, Jagu S, Karanam B, Day PM and Roden R, Virol J, 10/2009
- A synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of minor capsid protein L2 protects against heterologus human papillomavirus challenge, Alphs H
- Gambhira R
- Karanam B, Roberts JN, Jagu S, Schiller JT, Zeng W, Jackson DC, Roden RBS, Proceedings of the National Academy of Sciences, 04/2008
References
Available upon request
Timeline
Founder/Owner
MoleQular Labs, LLC
03.2023 - Current
CLIA Lab Director and Startup Consultant
Lighthouse Lab Services
03.2020 - 12.2022
Part-time CLIA Lab Director
GenoVive
12.2019 - 02.2020
Lab Director/Chief Scientific Officer
Dynamic Diagnostics
01.2019 - 01.2020
General Supervisor/Manager Molecular Platforms
Stone Clinical laboratories
09.2017 - 10.2018
Pharmacogenomics Lab Manager
Prima health
03.2016 - 07.2017
Instructor
Tulane University
01.2014 - 02.2016
Research Fellow
Tulane University
02.2008 - 01.2014
Postdoctoral Fellow
Johns Hopkins University
11.2002 - 02.2008
Research Trainee
MD Anderson Cancer Center
06.2000 - 11.2002
PhD - Biomedical Sciences
Tulane University
Master’s in veterinary sciences (M.V.Sc.) with Thesis - Animal Biotechnology
Indian Veterinary Research Institute
Bachelor’s veterinary Sciences (equal to DVM) - Animal Sciences
College of Veterinary Sciences
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